The Common Vein Copyright 2008
Definition
Acalculous cholecystitis is an inflammatory disease of the gallbladder, that is not related to stone disease and is primarily and initially a consequence of atony of the gallbladder caused by prolonged fasting and a consequent lack of CCK stimulation. The patients who have prolonged stay in the ICU and more specifically those who have sustained burns, trauma, or major surgical intervention – all entities that require prolonged ICU courses, are at risk for this enity. Although it often occurs in the inpatient setting, it may occasionally occur as an outpatient. Patients with hyperemesis gravidarum can present with acalculous cholecystitis.
Structurally the gallbladder shows distension and is without cholelithiasis. The failure of CCK stimulation from normal diet results in a gallbladder that is atonic, which becomes distended since bile is continually produced and not distributed.
Functionally the gallbladder is atonic and fails to transport the bile to the ampulla.
The tension on the wall renders it ischemic and susceptible to infarction, infection and bile infiltration. Hence cholecystitis supervenes.
The clinical presentation is usually a patient in the ICU who has a fever of unknown origin or who has right upper quadrant pain or tenderness with a positive Murphy’s sign.
From an imaging standpoint, ultrasound is the study of choice since. It shows findings similar to acute cholecystitis but no stones are present. The gallbladder is distended, the wall may be thickened, there may be fluid in the gallbladder fossa. Hyperemia is usually present, and probe tendernesss is commonly elicited when the patient is concious and communicative. CT is also useful particulalrly for the evaluation of changes in the surrounding fat which if present would suggest rupture of the wall..
Acalculous cholecystitis may complicated by gangrenous changes in the wall which could manifest radiologically with exteremely thin walls, empyema, abscess formation or perforation with bile peritonitis.
Acalculous cholecystitis is best treated with percutaneous cholecystostomy, which serves to decompress the gallbladder.
Ear11921.8b05b039.8s gallbladder distended enlarged dilated fluid fluid level gravity specific gravity sediment sludge cholestasis stasis Davidoff art copyright 2008 |
11921.8b05b043..8sb01 gallbladder distended tumefactive bile crank case oil thick sludge enlarged dilated fluid fluid level gravity specific gravity sediment sludge black cholestasis stasis Davidoff art copyright 2008 |
RUQ Pain, Distended Gallbladder, Tumefactive Bile |
The longitudinal view and transverse view of the gallbladder show mass like tumefactive bile. This is a sign of advancing cholestasis. The wall is not thickened and there is no fluid in the gallbladder fossa. Cholestasis and not cholecystitis is apparrent.
77717c01s right upper quadrant pain ICU setting RUQ pain gallbladder distended thick walled sludge cholestasis tumefactive bile fluid in gallbladder fossa small shadowing stones acalculous cholecystitis shape of tumefactive bile in the gallbladder has fetus like formation USscan ultrasound Courtesy Ashley DAvidoff MD copyright 2008 |
Acalculous Cholecystitis Crankcase Oil |
Pressure on the wall of the gallbladder causes ischemia and inflammation ensues. The diagram shows an inflamed wall (red) and the bile thickened tumefactive bile is becoming blacker in color. This color has been likened to crankcase oil in its color.
11921.8b05b043.8s gallbladder distended tumefactive bile thick sludge enlarged dilated fluid fluid level gravity specific gravity sediment sludge cholestasis stasis inflammation acalculous cholecystitis Davidoff art copyright 2008 |
Wall Rupture |
11921.8b05b043..8kb03 gallbladder distended tumefactive bile crank case oil thick sludge enlarged dilated fluid fluid level gravity specific gravity sediment sludge black cholestasis stasis wall inflammation acalculous cholecystitis complicated by perforation Davidoff art copyright 2008 |
11921.8b05b043.8b05s gallbladder distended tumefactive bile crank case oil thick sludge enlarged dilated fluid fluid level gravity specific gravity sediment sludge black cholestasis stasis wall inflammation acalculous cholecystitis complicated by perforation Davidoff art copyright 2008 |
If left untreated the wall can break down leading to leakage of bile into the peritoneal cavity causing bile peritonitis which is potentially lethal. The diagram shows leakage of bile into the peritoneal cavity and a severe rective inflammatory response.
11921.8b05b046.8b05 gallbladder distended tumefactive bile crank case oil thick sludge enlarged dilated fluid fluid level gravity specific gravity sediment sludge black cholestasis stasis wall inflammation acalculous cholecystitis complicated by perforation and bile peritonitis Davidoff art copyright 2008 |
77717c02s right upper quadrant pain ICU setting RUQ pain gallbladder distended thick walled hyperemic enhancing wall pericholecystic induration dirty fat stranding acalculous cholecystitis Courtesy Ashley DAvidoff MD copyright 2008 |
Release of bile salts is dependent upon CCK release. In the case of impaired secretion (such as in ICU patients), this can lead to several different pathologies, among which is non-calculus cholecystitis.<!–[if !supportFootnotes]–>
77680c01.8 right upper quadrant pain RUQ pain ICU setting gallbladder distended sludge cholestasis complex fluid in the gallbladder fossa acalculous cholecystitis USscan Courtesy Ashley Davidoff MD copyright 2008 |
16136c03.8s gallbladder prolonged ICU stay right upper quadrant pain right upper quadrant tenderness cholestasis enlarged tumefactive bile sludge thick walled acalculous cholecystitis percutaneous cholecystostomy ultrasound USscan Courtesy Ashley Davidoff MD copyright 2008 |
27222c01.8s 47F gallbladder indurated fat fluid anterior pararenal space Morrisons pouch perirenal space acalculous cholecystitis rupture perforation flattened IVC inferior vena cava dehydration decreased intravascular volume Courtesy Ashley Davidoff MD copyright 2008 |
and a distensded gallbladder26067c01.8cs gallbladder acalculous cholecystitis percutaneous cholecystostomy crankcase oil black bile CTscan Courtesy Ashley Davidoff MD copyright 2008 |
16136c01.8s gallbladder prolonged ICU stay right upper quadrant pain right upper quadrant tenderness cholestasis enlarged tumefactive bile sludge thick walled acalculous cholecystitis percutaneous cholecystostomy ultrasound USscan Courtesy Ashley Davidoff MD copyright 2008 |
77695c04.8s 32 female pregnant with hyperemesis gravidarum gallbladder distended painful sludge tumefactive bile percutaneous cholecystostomy USscan Courtesy Ashley Davidoff MD copyright 2008 |
78335c01.8s elderly female in ICU setting with pneumonia and ARDS and gastrostomy feeding tube. CTscan shows gallbladder distended and enlarged hyperemic thickened wall induration in the fat around the gallbladder gall stone cholelithiasis differential diagnosis includes acaclculous cholecystitis and calculous cholecystitis CTscan Courtesy Ashley DAvidoff copyright 2008 |